Comparative genomics of whole-cell pertussis vaccine strains from India
نویسندگان
چکیده
منابع مشابه
Comparative Assessment of the Whole-cell Pertussis Vaccine Potency Using Serological and Intracerebral Mouse Protection Methods
One of the most important QC tests of whole-cell pertussis vaccine (WCPV) is potency test. In this regard, mouse protection test (MPT) is the current potency method, which is associated with severe animal distress and large variability in results. The purpose of this study was to assess Pertussis Serological Potency Test (PSPT) as a serological alternative method to intracerebral challenge in M...
متن کاملImmunogenicity of a Triple Diphtheria-Tetanus-Whole Cell Pertussis Vaccine in Iranian Preschool Children
Background: Immunization against diphtheria, tetanus and pertussis has been applied in Iran since 1950. WHO suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (DTwP) vaccine, worldwide. Objectives: To determine the immunogenicity of locally manufactured DTwP vaccine administered to preschool children in a number of health centers of Tehran in 2...
متن کاملComparative genomics of prevaccination and modern Bordetella pertussis strains
Background: Despite vaccination since the 1950s, pertussis has persisted and resurged. It remains a m ajor cause o f in fan t death w o rld w id e and is the m ost prevalent vaccine-preventable disease in developed countries. The resurgence o f pertussis has been associated w ith the expansion o f Bordetella pertussis strains w ith a novel allele for the pertussis tox in (Ptx) prom oter, ptxP3,...
متن کاملWhole cell pertussis vaccine: reducing toxicity.
Since introduction of the pertussis vaccine in 1940's the morbidity and mortality due to the infection has been markedly reduced all over the world. However the adverse effects of the inactivated whole cell pertussis vaccine like pain, swelling at the site of injection, fever, vomiting anorexia, persistent crying & drowsiness have been the cause of great concern, till date. Also the safety conc...
متن کاملComplete Genome Sequences of Four Bordetella pertussis Vaccine Reference Strains from Serum Institute of India
Serum Institute of India is among the world's largest vaccine producers. Here, we report the complete genome sequences for four Bordetella pertussis strains used by Serum Institute of India in the production of whole-cell pertussis vaccines.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Genomics
سال: 2020
ISSN: 1471-2164
DOI: 10.1186/s12864-020-6724-8